Princess Louise of France was the youngest daughter of Philippe d’Orléans 1838–1894, Count of Paris and claimant to the French throne as „Philippe VII“. Her mother was Princess Marie Isabelle d’Orléans 1848–1919, daughter of Antoine, Duke of Montpensier, and Infanta Luisa Fernanda of Spain.
In the year 1907, Princess Louise of Orleans married Infant Carlos Prince of Bourbon Two Sicilies and widower of María de las Mercedes, Princess of Asturias.